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pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Powerful CYP3A4 inducers can minimize panobinostat ranges by ~70% and produce treatment method failure.pentobarbital will lower the level or outcome of osilodrostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism.How mu